Pro-vascular treatment after stroke:

High-Throughput Bioprinting of Geometrically-Controlled Pre-Vascularized Injectable Microgels for Accelerated Tissue Regeneration. Franca CM, Athirasala A, Subbiah R, Tahayeri A, Selvakumar P, Mansoorifar A, Horsophonphong S, Sercia A, Nih LR, Bertassoni LE. Adv Healthc Mater. 2023 May 23:e2202840. doi: 10.1002/adhm.202202840. PMID: 37219011.

Advances in Pancreatic Islet Transplantation Sites for the Treatment of Diabetes. Cayabyab F, Nih LR, Yoshihara E. Frontiers in Endocrinology. 2021 Sep 13;12:732431. doi: 10.3389/fendo.2021.732431.

Prenatal histological, cellular and molecular anomalies in trisomy 21 lung. The journal of pathology 2021.
Danopoulos S, Bhattacharya S, Deutsch G, Nih LR, Slaunwhite C, Mariani TJ, Al Alam D. J Pathol. 2021 Sep;255(1):41-51. doi: 10.1002/path.5735. Epub 2021 Jun 23. PMID: 34050678; PMCID: PMC9109699.

Systemic delivery of microRNA for treatment of brain ischemia. Chaoyong Liu, Jing Wen, Dai Li, Hongzhao Qi, Nih LR, Jialin Zhu, Duo Xu, Yu Ren, Shanshan Zhang, Donglin Han, Huanhuan Jia, Junhu Zhou, Meng Qin, Jialing Wu, Xubo Yuan, Ji Liu, Jin Zhao, Chunsheng Kang, Yunfeng Lu. Systemic delivery of microRNA for treatment of brain ischemia. Nano Res. 14, 3319–3328 (2021). https://doi.org/10.1007/s12274-021-3413-8

Engineered biomaterials for tissue regeneration of innervated and vascularized tissues: lessons learned from the brain
Nih LR.  J Endod 2020 Sept ;46:S101–S104

Pro-angiogenic regenerative therapies for the damaged brain: a tissue engineering approach
Nih LR, Carmichael ST, Segura T. (ed: Sharon Gerecht). Biophysical Regulation of Vascular Differentiation and Assembly. Biological and Medical Physics, Biomedical Engineering. Springer International Publishing. 2018 Nov (177-187)

Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke
Nih LR, Gojgini S,. Nature Materials. 2018 Jul;17(7):642-651

Hydrogels with precisely controlled integrin activation dictate vascular patterning and permeability
Li S, Nih LR, Bachman H, Fei P, Li Y, Nam E, Barker TH, Segura T. Nature Materials. 2017 Sep;16(9):953-961

Enzyme-responsive delivery of multiple proteins with spatiotemporal control.  Zhu S, Nih LR, Carmichael ST, Lu Y, Segura T.  Advanced Materials, 2015 Jun 24;27(24):3620-5.

Dll4-notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models. Cristofaro B, Shi Y, Faria M, Suchting S, Leroyer A, Trindade A, Duarte A, Zovein A, Arispe L, Nih LR, Kubis N, Loufrani L, Henrion D, Todiras M, Schleifenbaum J, Gollasch M, Zuang Z, Simons M, Eichmann A, Le Noble F. Development. 2013 Apr;140(8):1720-9.

Neuroblast survival depends on mature vascular network formation after mouse stroke: role of endothelial and smooth muscle progenitor cell co-administration.  Nih LR, Deroide N, Déan C, Lerouet D, Soustrat M, Levy BI, Pocard M, Margaill I, Kubis N. European Journal of Neuroscience, 2012; 35:1208-1217.

Stem cell therapy after stroke:

Brain pericytes derived from human pluripotent stem cells retain vascular and phagocytic functions under hypoxia. Kim Y, Zhang M, Bosworth A, Julia TCW, Nih LR, Kisler K, Sagare AP, Rust R. Stem Cells. 2025:sxaf055. doi:10.1093/stmcls/sxaf055

Delayed Transplantation of Neural Stem Cells Improves Initial Graft Survival after Stroke. Weber RZ, Rentsch NH, Achón Buil B, Nih LR, Tackenberg C, Rust R. Advanced Science, e04154, 2025. doi.org/10.1002/advs.202504154

Brain repair mechanisms after cell therapy for stroke. Rust R, Nih LR, Liberale L, Yin H, El Amki M, Ong LK, Zlokovic BV. Brain. 2024 Oct 3;147(10):3286-3305. doi: 10.1093/brain/awae204. PMID: 38916992; PMCID: PMC11449145.

Brain transplantation of genetically corrected Sanfilippo B Neural Stem Cells induces partial cross-correction of the disease. Pearse Y, Clarke C, Kan S, Le S. Q., Sanghez V, Luzzi A, Pham I, Nih LR., Cooper J. D., Dickson P. I., Iacovino M. Mol Ther Methods Clin Dev. 2022 Oct 27;27:452-463. doi: 10.1016/j.omtm.2022.10.013. PMID: 36419468; PMCID: PMC9672419.

Efficient delivery of nerve growth factors to the central nervous system for neural regeneration
Xu D, Wu D, Qin M, Nih LR, Liu C, Cao Z, Ren J, Chen X, He Z, Yu W, Guan J, Duan S, Liu F, Liu X, Li J, Harley D, Xu B, Hou L, Chen ISY, Wen J, Chen W, Pourtaheri S, Lu Y.  Advanced Materials. 2019 Aug;31(33):e1900727

Engineered ha hydrogel for stem cell transplantation in the brain: biocompatibility data using a design of experiment approach. Nih LR, Moshayedi P, Llorente IL, Berg AR, Cinkornpumin J, Lowry WE, Segura T, Carmichael ST. Data in Brief. 2016 Nov 24;10:202-209.

Systematic optimization of an engineered hydrogel allows for selective control of human neural stem cell survival and differentiation after transplantation in the stroke brain. Nih LR, Moshayedi P, Lorenzo Llorente I, Cinkornpumin J, Lowry WE, Segura T, Carmichael ST. Biomaterials. 2016 Oct;105:145-55.

Stem cell therapy in stroke: where are we now? Nih LR, Levy BI, Kubis N.  Sang Thrombose Vaisseaux. 2012;24:119-124.

Stem cells: where do they fit in the treatment of stroke. Nih LR, Kubis N.  Pratique Neurologique, 2012; 3:175-180.

Immunomodulation after stroke:

Injection of microporous annealing particle (map) hydrogels in the stroke cavity reduces gliosis and inflammation and promotes npc migration to the lesion
Nih LR, Sideris E, Carmichael ST, Segura T. Advanced Materials. 2017 Aug;29(32)

Hydrogels for brain repair after stroke: an emerging treatment option. Nih LR, Carmichael ST, Segura T.  Current Opinion in Biotechnology. 2016 May 6;40:155-163.

Mfge8 inhibits inflammasome-induced il-1β production and limits postischemic cerebral injury. Deroide N, Nih LR, Lerouet D, Vilar J, Guerin C, Lévy BI, Margaill I, Pocard M, mallat Z, Kubis N. Journal of Clinical Investigation. 2013 Mar 1;123(3):1176-81.

Cerebral plasticity: from bench to bedside in stroke treatment. Deroide N, Nih LR, Tran Dinh RY, Lévy BI, Kubis N. Revue de Medecine Interne, 2010 Jul;31(7):486-492.

Lina R. Nih, Ph.D.
Assistant Professor
Kirk Kerkorian School of Medicine
University of Nevada, Las Vegas (UNLV)
lina.nih@unlv.edu